HPS4-UBE2L3 Fusion FISH Probe
The HPS4-UBE2L3 Fusion FISH Probe is used to confirm a fusion of the HPS4 and UBE2L3 genes. The fusion of the HPS4 and UBE2L3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HPS4-UBE2L3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-RERE | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-REOR | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-REGO | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-REGR | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-REAQ | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-ORRE | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-OROR | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-ORGO | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-ORAQ | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-GORE | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-GOOR | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-GOGO | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-GOGR | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-GOAQ | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-GRRE | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-GROR | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-GRGO | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-GRGR | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-GRAQ | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-AQRE | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-AQOR | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-AQGO | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-AQGR | 20 (40 μL) | 200 μL |
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| HPS4-UBE2L3-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE2L3 Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Name: Ubiquitin Conjugating Enzyme E2 L3
Chromosome: CHR22: 21921956 -21978323
Locus: 22q11.21
HPS4 Gene Summary
This gene encodes a protein component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in this gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Name: HPS4, Biogenesis Of Lysosomal Organelles Complex 3 Subunit 2
Chromosome: CHR22: 26847445 -26879820
Locus: 22q12.1
Gene Diseases
The HPS4 UBE2L3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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