HPGD-GUCY1A3 Fusion FISH Probe
The HPGD-GUCY1A3 Fusion FISH Probe is used to confirm a fusion of the HPGD and GUCY1A3 genes. The fusion of the HPGD and GUCY1A3 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HPGD-GUCY1A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-RERE | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-REOR | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-REGO | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-REGR | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-REAQ | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-ORRE | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-OROR | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-ORGO | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-ORAQ | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-GORE | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-GOOR | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-GOGO | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-GOGR | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-GOAQ | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-GRRE | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-GROR | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-GRGO | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-GRGR | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-GRAQ | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-AQRE | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-AQOR | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-AQGO | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-AQGR | 20 (40 μL) | 200 μL |
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| HPGD-GUCY1A3-20-AQAQ | 20 (40 μL) | 200 μL |
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GUCY1A3 Gene Summary
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Guanylate Cyclase 1 Soluble Subunit Alpha
Chromosome: CHR4: 156588148 -156658214
Locus: 4q32.1
HPGD Gene Summary
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Name: 15-hydroxyprostaglandin Dehydrogenase
Chromosome: CHR4: 175411327 -175444044
Locus: 4q34.1
Gene Diseases
The HPGD GUCY1A3 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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