HP-EEA1 Fusion FISH Probe
The HP-EEA1 Fusion FISH Probe is used to confirm a fusion of the HP and EEA1 genes. The fusion of the HP and EEA1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HP-EEA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-RERE | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-REOR | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-REGO | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-REGR | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-REAQ | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-ORRE | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-OROR | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-ORGO | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-GORE | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-GOOR | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-GOGO | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-GOGR | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-GRRE | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-GROR | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-GRGO | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-GRGR | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-AQRE | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-AQOR | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-AQGO | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-AQGR | 20 (40 μL) | 200 μL |
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| HP-EEA1-20-AQAQ | 20 (40 μL) | 200 μL |
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HP Gene Summary
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Gene Name: Haptoglobin
Chromosome: CHR16: 72088507 -72094955
Locus: 16q22.2
EEA1 Gene Summary
The Early Endosome Antigen 1 (EEA1) gene is located on chr12 :93166284-93323107 at 12q22.
Gene Name: Early Endosome Antigen 1
Chromosome: CHR12: 93166284 -93323107
Locus: 12q22
Gene Diseases
The HP EEA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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