HOXB6-EPHA5 Fusion FISH Probe
The HOXB6-EPHA5 Fusion FISH Probe is used to confirm a fusion of the HOXB6 and EPHA5 genes. The fusion of the HOXB6 and EPHA5 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HOXB6-EPHA5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-RERE | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-REOR | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-REGO | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-REGR | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-REAQ | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-ORRE | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-OROR | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-ORGO | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-ORAQ | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-GORE | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-GOOR | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-GOGO | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-GOGR | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-GOAQ | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-GRRE | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-GROR | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-GRGO | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-GRGR | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-GRAQ | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-AQRE | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-AQOR | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-AQGO | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-AQGR | 20 (40 μL) | 200 μL |
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| HOXB6-EPHA5-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHA5 Gene Summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
Gene Name: EPH Receptor A5
Chromosome: CHR4: 66185280 -66535653
Locus: 4q13.1-q13.2
HOXB6 Gene Summary
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008]
Gene Name: Homeobox B6
Chromosome: CHR17: 46673098 -46682334
Locus: 17q21.32
Gene Diseases
The HOXB6 EPHA5 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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