HOXB3-TCF12 Fusion FISH Probe
The HOXB3-TCF12 Fusion FISH Probe is used to confirm a fusion of the HOXB3 and TCF12 genes. The fusion of the HOXB3 and TCF12 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HOXB3-TCF12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-RERE | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-REOR | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-REGO | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-REGR | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-REAQ | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-ORRE | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-OROR | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-ORGO | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-ORAQ | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-GORE | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-GOOR | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-GOGO | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-GOGR | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-GOAQ | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-GRRE | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-GROR | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-GRGO | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-GRGR | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-GRAQ | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-AQRE | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-AQOR | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-AQGO | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-AQGR | 20 (40 μL) | 200 μL |
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| HOXB3-TCF12-20-AQAQ | 20 (40 μL) | 200 μL |
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HOXB3 Gene Summary
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]
Gene Name: Homeobox B3
Chromosome: CHR17: 46626231 -46651810
Locus: 17q21.32
TCF12 Gene Summary
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Transcription Factor 12
Chromosome: CHR15: 57210832 -57580714
Locus: 15q21.3
Gene Diseases
The HOXB3 TCF12 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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