HOOK3-IKBKB Fusion FISH Probe
The HOOK3-IKBKB Fusion FISH Probe is used to confirm a fusion of the HOOK3 and IKBKB genes. The fusion of the HOOK3 and IKBKB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HOOK3-IKBKB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-RERE | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-REOR | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-REGO | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-REGR | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-REAQ | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-ORRE | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-OROR | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-ORGO | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-ORAQ | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-GORE | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-GOOR | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-GOGO | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-GOGR | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-GOAQ | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-GRRE | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-GROR | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-GRGO | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-GRGR | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-GRAQ | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-AQRE | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-AQOR | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-AQGO | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-AQGR | 20 (40 μL) | 200 μL |
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| HOOK3-IKBKB-20-AQAQ | 20 (40 μL) | 200 μL |
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IKBKB Gene Summary
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Name: Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta
Chromosome: CHR8: 42128819 -42190171
Locus: 8p11.21
HOOK3 Gene Summary
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Gene Name: Hook Microtubule Tethering Protein 3
Chromosome: CHR8: 42752032 -42885682
Locus: 8p11.21
Gene Diseases
The HOOK3 IKBKB Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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