HNRNPR-E2F2 Fusion FISH Probe
The HNRNPR-E2F2 Fusion FISH Probe is used to confirm a fusion of the HNRNPR and E2F2 genes. The fusion of the HNRNPR and E2F2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HNRNPR-E2F2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-RERE | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-REOR | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-REGO | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-REGR | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-REAQ | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-ORRE | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-OROR | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-ORGO | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-GORE | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-GOOR | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-GOGO | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-GOGR | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-GRRE | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-GROR | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-GRGO | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-GRGR | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-AQRE | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-AQOR | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-AQGO | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-AQGR | 20 (40 μL) | 200 μL |
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| HNRNPR-E2F2-20-AQAQ | 20 (40 μL) | 200 μL |
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E2F2 Gene Summary
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
Gene Name: E2F Transcription Factor 2
Chromosome: CHR1: 23832919 -23857712
Locus: 1p36.12
HNRNPR Gene Summary
This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]
Gene Name: Heterogeneous Nuclear Ribonucleoprotein R
Chromosome: CHR1: 23636275 -23670853
Locus: 1p36.12
Gene Diseases
The HNRNPR E2F2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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