HNRNPM-PC Fusion FISH Probe
The HNRNPM-PC Fusion FISH Probe is used to confirm a fusion of the HNRNPM and PC genes. The fusion of the HNRNPM and PC genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HNRNPM-PC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-RERE | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-REOR | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-REGO | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-REGR | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-REAQ | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-ORRE | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-OROR | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-ORGO | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-ORAQ | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-GORE | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-GOOR | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-GOGO | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-GOGR | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-GOAQ | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-GRRE | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-GROR | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-GRGO | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-GRGR | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-GRAQ | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-AQRE | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-AQOR | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-AQGO | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-AQGR | 20 (40 μL) | 200 μL |
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| HNRNPM-PC-20-AQAQ | 20 (40 μL) | 200 μL |
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HNRNPM Gene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Heterogeneous Nuclear Ribonucleoprotein M
Chromosome: CHR19: 8509802 -8554002
Locus: 19p13.2
PC Gene Summary
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Pyruvate Carboxylase
Chromosome: CHR11: 66615996 -66725847
Locus: 11q13.2
Gene Diseases
The HNRNPM PC Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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