HNRNPL-SIRT2 Fusion FISH Probe
The HNRNPL-SIRT2 Fusion FISH Probe is used to confirm a fusion of the HNRNPL and SIRT2 genes. The fusion of the HNRNPL and SIRT2 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HNRNPL-SIRT2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| HNRNPL-SIRT2-20-AQAQ | 20 (40 μL) | 200 μL |
|
HNRNPL Gene Summary
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Heterogeneous Nuclear Ribonucleoprotein L
Chromosome: CHR19: 39327027 -39342979
Locus: 19q13.2
SIRT2 Gene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Gene Name: Sirtuin 2
Chromosome: CHR19: 39369194 -39390502
Locus: 19q13.2
Gene Diseases
The HNRNPL SIRT2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|