HNRNPL-ACTN4 Fusion FISH Probe
The HNRNPL-ACTN4 Fusion FISH Probe is used to confirm a fusion of the HNRNPL and ACTN4 genes. The fusion of the HNRNPL and ACTN4 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HNRNPL-ACTN4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-RERE | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-REOR | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-REGO | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-REGR | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-REAQ | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-ORRE | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-OROR | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-ORGO | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-ORAQ | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-GORE | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-GOOR | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-GOGO | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-GOGR | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-GOAQ | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-GRRE | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-GROR | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-GRGO | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-GRGR | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-GRAQ | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-AQRE | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-AQOR | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-AQGO | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-AQGR | 20 (40 μL) | 200 μL |
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| HNRNPL-ACTN4-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTN4 Gene Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Gene Name: Actinin Alpha 4
Chromosome: CHR19: 39138266 -39221171
Locus: 19q13.2
HNRNPL Gene Summary
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Heterogeneous Nuclear Ribonucleoprotein L
Chromosome: CHR19: 39327027 -39342979
Locus: 19q13.2
Gene Diseases
The HNRNPL ACTN4 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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