HNRNPH3-KLK1 Fusion FISH Probe
The HNRNPH3-KLK1 Fusion FISH Probe is used to confirm a fusion of the HNRNPH3 and KLK1 genes. The fusion of the HNRNPH3 and KLK1 genes has been associated with Kidney Chromophobe. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HNRNPH3-KLK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-RERE | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-REOR | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-REGO | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-REGR | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-REAQ | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-ORRE | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-OROR | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-ORGO | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-GORE | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-GOOR | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-GOGO | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-GOGR | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-GRRE | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-GROR | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-GRGO | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-GRGR | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-AQRE | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-AQOR | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-AQGO | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-AQGR | 20 (40 μL) | 200 μL |
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| HNRNPH3-KLK1-20-AQAQ | 20 (40 μL) | 200 μL |
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HNRNPH3 Gene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Heterogeneous Nuclear Ribonucleoprotein H3
Chromosome: CHR10: 70091767 -70102953
Locus: 10q21.3
KLK1 Gene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
Gene Name: Kallikrein 1
Chromosome: CHR19: 51322403 -51327043
Locus: 19q13.33
Gene Diseases
The HNRNPH3 KLK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Chromophobe |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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