HNRNPH1-RNF130 Fusion FISH Probe
The HNRNPH1-RNF130 Fusion FISH Probe is used to confirm a fusion of the HNRNPH1 and RNF130 genes. The fusion of the HNRNPH1 and RNF130 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HNRNPH1-RNF130-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-RERE | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-REOR | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-REGO | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-REGR | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-REAQ | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-ORRE | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-OROR | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-ORGO | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-ORAQ | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-GORE | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-GOOR | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-GOGO | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-GOGR | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-GOAQ | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-GRRE | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-GROR | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-GRGO | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-GRGR | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-GRAQ | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-AQRE | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-AQOR | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-AQGO | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-AQGR | 20 (40 μL) | 200 μL |
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| HNRNPH1-RNF130-20-AQAQ | 20 (40 μL) | 200 μL |
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HNRNPH1 Gene Summary
This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]
Gene Name: Heterogeneous Nuclear Ribonucleoprotein H1
Chromosome: CHR5: 179041178 -179050722
Locus: 5q35.3
RNF130 Gene Summary
The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Ring Finger Protein 130
Chromosome: CHR5: 179382473 -179499109
Locus: 5q35.3
Gene Diseases
The HNRNPH1 RNF130 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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