HNRNPH1-ERG Fusion FISH Probe
The HNRNPH1-ERG Fusion FISH Probe is used to confirm a fusion of the HNRNPH1 and ERG genes. The fusion of the HNRNPH1 and ERG genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HNRNPH1-ERG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-RERE | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-REOR | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-REGO | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-REGR | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-REAQ | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-ORRE | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-OROR | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-ORGO | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-ORAQ | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-GORE | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-GOOR | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-GOGO | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-GOGR | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-GOAQ | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-GRRE | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-GROR | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-GRGO | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-GRGR | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-GRAQ | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-AQRE | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-AQOR | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-AQGO | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-AQGR | 20 (40 μL) | 200 μL |
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| HNRNPH1-ERG-20-AQAQ | 20 (40 μL) | 200 μL |
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ERG Gene Summary
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Gene Name: ERG, ETS Transcription Factor
Chromosome: CHR21: 39739182 -40033618
Locus: 21q22.2
HNRNPH1 Gene Summary
This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]
Gene Name: Heterogeneous Nuclear Ribonucleoprotein H1
Chromosome: CHR5: 179041178 -179050722
Locus: 5q35.3
Gene Diseases
The HNRNPH1 ERG Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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