HMGXB3-PAM Fusion FISH Probe
The HMGXB3-PAM Fusion FISH Probe is used to confirm a fusion of the HMGXB3 and PAM genes. The fusion of the HMGXB3 and PAM genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HMGXB3-PAM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-RERE | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-REOR | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-REGO | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-REGR | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-REAQ | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-ORRE | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-OROR | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-ORGO | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-ORAQ | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-GORE | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-GOOR | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-GOGO | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-GOGR | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-GOAQ | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-GRRE | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-GROR | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-GRGO | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-GRGR | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-GRAQ | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-AQRE | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-AQOR | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-AQGO | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-AQGR | 20 (40 μL) | 200 μL |
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| HMGXB3-PAM-20-AQAQ | 20 (40 μL) | 200 μL |
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PAM Gene Summary
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Peptidylglycine Alpha-amidating Monooxygenase
Chromosome: CHR5: 102201526 -102366808
Locus: 5q21.1
HMGXB3 Gene Summary
This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]
Gene Name: HMG-box Containing 3
Chromosome: CHR5: 149380168 -149432706
Locus: 5q32
Gene Diseases
The HMGXB3 PAM Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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