HMGA2-PCBP2 Fusion FISH Probe
The HMGA2-PCBP2 Fusion FISH Probe is used to confirm a fusion of the HMGA2 and PCBP2 genes. The fusion of the HMGA2 and PCBP2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HMGA2-PCBP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-RERE | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-REOR | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-REGO | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-REGR | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-REAQ | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-ORRE | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-OROR | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-ORGO | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-GORE | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-GOOR | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-GOGO | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-GOGR | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-GRRE | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-GROR | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-GRGO | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-GRGR | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-AQRE | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-AQOR | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-AQGO | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-AQGR | 20 (40 μL) | 200 μL |
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| HMGA2-PCBP2-20-AQAQ | 20 (40 μL) | 200 μL |
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PCBP2 Gene Summary
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
Gene Name: Poly(rC) Binding Protein 2
Chromosome: CHR12: 53845885 -53874946
Locus: 12q13.13
HMGA2 Gene Summary
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: High Mobility Group AT-hook 2
Chromosome: CHR12: 66218239 -66360071
Locus: 12q14.3
Gene Diseases
The HMGA2 PCBP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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