HMGA2-NUP107 Fusion FISH Probe
The HMGA2-NUP107 Fusion FISH Probe is used to confirm a fusion of the HMGA2 and NUP107 genes. The fusion of the HMGA2 and NUP107 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HMGA2-NUP107-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-RERE | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-REOR | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-REGO | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-REGR | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-REAQ | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-ORRE | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-OROR | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-ORGO | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-ORAQ | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-GORE | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-GOOR | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-GOGO | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-GOGR | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-GOAQ | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-GRRE | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-GROR | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-GRGO | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-GRGR | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-GRAQ | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-AQRE | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-AQOR | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-AQGO | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-AQGR | 20 (40 μL) | 200 μL |
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| HMGA2-NUP107-20-AQAQ | 20 (40 μL) | 200 μL |
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HMGA2 Gene Summary
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: High Mobility Group AT-hook 2
Chromosome: CHR12: 66218239 -66360071
Locus: 12q14.3
NUP107 Gene Summary
This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Nucleoporin 107
Chromosome: CHR12: 69080730 -69136473
Locus: 12q15
Gene Diseases
The HMGA2 NUP107 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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