HMBOX1-MCM3 Fusion FISH Probe
The HMBOX1-MCM3 Fusion FISH Probe is used to confirm a fusion of the HMBOX1 and MCM3 genes. The fusion of the HMBOX1 and MCM3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HMBOX1-MCM3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-RERE | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-REOR | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-REGO | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-REGR | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-REAQ | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-ORRE | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-OROR | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-ORGO | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-ORAQ | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-GORE | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-GOOR | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-GOGO | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-GOGR | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-GOAQ | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-GRRE | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-GROR | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-GRGO | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-GRGR | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-GRAQ | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-AQRE | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-AQOR | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-AQGO | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-AQGR | 20 (40 μL) | 200 μL |
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| HMBOX1-MCM3-20-AQAQ | 20 (40 μL) | 200 μL |
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MCM3 Gene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Minichromosome Maintenance Complex Component 3
Chromosome: CHR6: 52128811 -52149582
Locus: 6p12.2
HMBOX1 Gene Summary
The Homeobox Containing 1 (HMBOX1) gene is located on chr8 :28747910-28910242 at 8p21.1-p12.
Gene Name: Homeobox Containing 1
Chromosome: CHR8: 28747910 -28910242
Locus: 8p21.1-p12
Gene Diseases
The HMBOX1 MCM3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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