HLA-DRA-SNW1 Fusion FISH Probe
The HLA-DRA-SNW1 Fusion FISH Probe is used to confirm a fusion of the HLA-DRA and SNW1 genes. The fusion of the HLA-DRA and SNW1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-DRA-SNW1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-DRA-SNW1-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-DRA Gene Summary
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class II, DR Alpha
Chromosome: CHR6_mann_hap4: 3749678 -3754894
Locus: 6p21.32
SNW1 Gene Summary
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: SNW Domain Containing 1
Chromosome: CHR14: 78183943 -78227497
Locus: 14q24.3
Gene Diseases
The HLA-DRA SNW1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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