HLA-DRA-EEA1 Fusion FISH Probe
The HLA-DRA-EEA1 Fusion FISH Probe is used to confirm a fusion of the HLA-DRA and EEA1 genes. The fusion of the HLA-DRA and EEA1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-DRA-EEA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-DRA-EEA1-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-DRA Gene Summary
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class II, DR Alpha
Chromosome: CHR6_mann_hap4: 3749678 -3754894
Locus: 6p21.32
EEA1 Gene Summary
The Early Endosome Antigen 1 (EEA1) gene is located on chr12 :93166284-93323107 at 12q22.
Gene Name: Early Endosome Antigen 1
Chromosome: CHR12: 93166284 -93323107
Locus: 12q22
Gene Diseases
The HLA-DRA EEA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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