HLA-DPA1-TRIP12 Fusion FISH Probe
The HLA-DPA1-TRIP12 Fusion FISH Probe is used to confirm a fusion of the HLA-DPA1 and TRIP12 genes. The fusion of the HLA-DPA1 and TRIP12 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-DPA1-TRIP12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-TRIP12-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-DPA1 Gene Summary
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class II, DP Alpha 1
Chromosome: CHR6_mann_hap4: 4489885 -4506101
Locus: 6p21.32
TRIP12 Gene Summary
The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
Gene Name: Thyroid Hormone Receptor Interactor 12
Chromosome: CHR2: 230631929 -230786655
Locus: 2q36.3
Gene Diseases
The HLA-DPA1 TRIP12 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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