HLA-DPA1-SQSTM1 Fusion FISH Probe
The HLA-DPA1-SQSTM1 Fusion FISH Probe is used to confirm a fusion of the HLA-DPA1 and SQSTM1 genes. The fusion of the HLA-DPA1 and SQSTM1 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-DPA1-SQSTM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-DPA1-SQSTM1-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-DPA1 Gene Summary
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class II, DP Alpha 1
Chromosome: CHR6_mann_hap4: 4489885 -4506101
Locus: 6p21.32
SQSTM1 Gene Summary
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
Gene Name: Sequestosome 1
Chromosome: CHR5: 179233387 -179265077
Locus: 5q35.3
Gene Diseases
The HLA-DPA1 SQSTM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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