HLA-C-TYK2 Fusion FISH Probe
The HLA-C-TYK2 Fusion FISH Probe is used to confirm a fusion of the HLA-C and TYK2 genes. The fusion of the HLA-C and TYK2 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-C-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-C-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-C Gene Summary
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, C
Chromosome: CHR6: 31236525 -31239913
Locus: 6p21.33
TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
Gene Diseases
The HLA-C TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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