HLA-C-FOXP1 Fusion FISH Probe
The HLA-C-FOXP1 Fusion FISH Probe is used to confirm a fusion of the HLA-C and FOXP1 genes. The fusion of the HLA-C and FOXP1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-C-FOXP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-C-FOXP1-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-C Gene Summary
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, C
Chromosome: CHR6: 31236525 -31239913
Locus: 6p21.33
FOXP1 Gene Summary
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Forkhead Box P1
Chromosome: CHR3: 71004735 -71633140
Locus: 3p13
Gene Diseases
The HLA-C FOXP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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