HLA-C-FADS2 Fusion FISH Probe
The HLA-C-FADS2 Fusion FISH Probe is used to confirm a fusion of the HLA-C and FADS2 genes. The fusion of the HLA-C and FADS2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-C-FADS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-C-FADS2-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-C Gene Summary
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, C
Chromosome: CHR6: 31236525 -31239913
Locus: 6p21.33
FADS2 Gene Summary
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Name: Fatty Acid Desaturase 2
Chromosome: CHR11: 61595712 -61634825
Locus: 11q12.2
Gene Diseases
The HLA-C FADS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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