HLA-C-DDX21 Fusion FISH Probe
The HLA-C-DDX21 Fusion FISH Probe is used to confirm a fusion of the HLA-C and DDX21 genes. The fusion of the HLA-C and DDX21 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-C-DDX21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-C-DDX21-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-C Gene Summary
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, C
Chromosome: CHR6: 31236525 -31239913
Locus: 6p21.33
DDX21 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Gene Name: DExD-box Helicase 21
Chromosome: CHR10: 70715891 -70744279
Locus: 10q22.1
Gene Diseases
The HLA-C DDX21 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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