HLA-B-UBR5 Fusion FISH Probe
The HLA-B-UBR5 Fusion FISH Probe is used to confirm a fusion of the HLA-B and UBR5 genes. The fusion of the HLA-B and UBR5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-B-UBR5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-B-UBR5-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-B Gene Summary
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, B
Chromosome: CHR6_mcf_hap5: 2701428 -2704782
Locus: 6p21.33
UBR5 Gene Summary
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Protein Ligase E3 Component N-recognin 5
Chromosome: CHR8: 103264501 -103424917
Locus: 8q22.3
Gene Diseases
The HLA-B UBR5 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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