HLA-B-SNW1 Fusion FISH Probe
The HLA-B-SNW1 Fusion FISH Probe is used to confirm a fusion of the HLA-B and SNW1 genes. The fusion of the HLA-B and SNW1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-B-SNW1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-B-SNW1-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-B Gene Summary
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, B
Chromosome: CHR6_mcf_hap5: 2701428 -2704782
Locus: 6p21.33
SNW1 Gene Summary
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: SNW Domain Containing 1
Chromosome: CHR14: 78183943 -78227497
Locus: 14q24.3
Gene Diseases
The HLA-B SNW1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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