HLA-B-EIF2AK2 Fusion FISH Probe
The HLA-B-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the HLA-B and EIF2AK2 genes. The fusion of the HLA-B and EIF2AK2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-B-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-B-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-B Gene Summary
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, B
Chromosome: CHR6_mcf_hap5: 2701428 -2704782
Locus: 6p21.33
EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
Gene Diseases
The HLA-B EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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