HLA-B-CLCN3 Fusion FISH Probe
The HLA-B-CLCN3 Fusion FISH Probe is used to confirm a fusion of the HLA-B and CLCN3 genes. The fusion of the HLA-B and CLCN3 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HLA-B-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| HLA-B-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
|
CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
HLA-B Gene Summary
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, B
Chromosome: CHR6_mcf_hap5: 2701428 -2704782
Locus: 6p21.33
Gene Diseases
The HLA-B CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|