HLA-B-CFB Fusion FISH Probe
The HLA-B-CFB Fusion FISH Probe is used to confirm a fusion of the HLA-B and CFB genes. The fusion of the HLA-B and CFB genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-B-CFB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-B-CFB-20-AQAQ | 20 (40 μL) | 200 μL |
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CFB Gene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Gene Name: Complement Factor B
Chromosome: CHR6_dbb_hap3: 3199308 -3205449
Locus: 6p21.33
HLA-B Gene Summary
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, B
Chromosome: CHR6_mcf_hap5: 2701428 -2704782
Locus: 6p21.33
Gene Diseases
The HLA-B CFB Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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