HLA-B-CCT5 Fusion FISH Probe
The HLA-B-CCT5 Fusion FISH Probe is used to confirm a fusion of the HLA-B and CCT5 genes. The fusion of the HLA-B and CCT5 genes has been associated with Kidney Renal Clear Cell Carcinoma, and Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-B-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| HLA-B-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-B Gene Summary
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, B
Chromosome: CHR6_mcf_hap5: 2701428 -2704782
Locus: 6p21.33
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The HLA-B CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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