HIVEP3-DOT1L Fusion FISH Probe
The HIVEP3-DOT1L Fusion FISH Probe is used to confirm a fusion of the HIVEP3 and DOT1L genes. The fusion of the HIVEP3 and DOT1L genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HIVEP3-DOT1L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-RERE | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-REOR | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-REGO | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-REGR | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-REAQ | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-ORRE | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-OROR | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-ORGO | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-ORAQ | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-GORE | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-GOOR | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-GOGO | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-GOGR | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-GOAQ | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-GRRE | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-GROR | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-GRGO | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-GRGR | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-GRAQ | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-AQRE | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-AQOR | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-AQGO | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-AQGR | 20 (40 μL) | 200 μL |
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| HIVEP3-DOT1L-20-AQAQ | 20 (40 μL) | 200 μL |
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HIVEP3 Gene Summary
This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]
Gene Name: Human Immunodeficiency Virus Type I Enhancer Binding Protein 3
Chromosome: CHR1: 41975683 -42384496
Locus: 1p34.2
DOT1L Gene Summary
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Gene Name: DOT1 Like Histone Lysine Methyltransferase
Chromosome: CHR19: 2164147 -2232577
Locus: 19p13.3
Gene Diseases
The HIVEP3 DOT1L Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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