HIST2H2BE-NDUFV1 Fusion FISH Probe
The HIST2H2BE-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the HIST2H2BE and NDUFV1 genes. The fusion of the HIST2H2BE and NDUFV1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HIST2H2BE-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| HIST2H2BE-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
HIST2H2BE Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. [provided by RefSeq, Aug 2015]
Gene Name: Histone Cluster 2 H2B Family Member E
Chromosome: CHR1: 149856009 -149858232
Locus: 1q21.2
Gene Diseases
The HIST2H2BE NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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