HIST1H2AC-TNFRSF21 Fusion FISH Probe
The HIST1H2AC-TNFRSF21 Fusion FISH Probe is used to confirm a fusion of the HIST1H2AC and TNFRSF21 genes. The fusion of the HIST1H2AC and TNFRSF21 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HIST1H2AC-TNFRSF21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-RERE | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-REOR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-REGO | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-REGR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-REAQ | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-ORRE | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-OROR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-ORGO | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-ORAQ | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-GORE | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-GOOR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-GOGO | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-GOGR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-GOAQ | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-GRRE | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-GROR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-GRGO | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-GRGR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-GRAQ | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-AQRE | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-AQOR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-AQGO | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-AQGR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-TNFRSF21-20-AQAQ | 20 (40 μL) | 200 μL |
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HIST1H2AC Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Gene Name: Histone Cluster 1 H2A Family Member C
Chromosome: CHR6: 26124372 -26124918
Locus: 6p22.2
TNFRSF21 Gene Summary
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
Gene Name: TNF Receptor Superfamily Member 21
Chromosome: CHR6: 47199267 -47277680
Locus: 6p12.3
Gene Diseases
The HIST1H2AC TNFRSF21 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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