HIRA-ZBTB16 Fusion FISH Probe
The HIRA-ZBTB16 Fusion FISH Probe is used to confirm a fusion of the HIRA and ZBTB16 genes. The fusion of the HIRA and ZBTB16 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HIRA-ZBTB16-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-RERE | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-REOR | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-REGO | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-REGR | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-REAQ | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-ORRE | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-OROR | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-ORGO | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-ORAQ | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-GORE | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-GOOR | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-GOGO | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-GOGR | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-GOAQ | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-GRRE | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-GROR | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-GRGO | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-GRGR | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-GRAQ | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-AQRE | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-AQOR | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-AQGO | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-AQGR | 20 (40 μL) | 200 μL |
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| HIRA-ZBTB16-20-AQAQ | 20 (40 μL) | 200 μL |
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HIRA Gene Summary
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
Gene Name: Histone Cell Cycle Regulator
Chromosome: CHR22: 19318223 -19419219
Locus: 22q11.21
ZBTB16 Gene Summary
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Zinc Finger And BTB Domain Containing 16
Chromosome: CHR11: 113930430 -114121397
Locus: 11q23.2
Gene Diseases
The HIRA ZBTB16 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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