HIRA-NSMCE2 Fusion FISH Probe
The HIRA-NSMCE2 Fusion FISH Probe is used to confirm a fusion of the HIRA and NSMCE2 genes. The fusion of the HIRA and NSMCE2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HIRA-NSMCE2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-RERE | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-REOR | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-REGO | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-REGR | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-REAQ | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-ORRE | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-OROR | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-ORGO | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-GORE | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-GOOR | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-GOGO | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-GOGR | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-GRRE | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-GROR | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-GRGO | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-GRGR | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-AQRE | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-AQOR | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-AQGO | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-AQGR | 20 (40 μL) | 200 μL |
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| HIRA-NSMCE2-20-AQAQ | 20 (40 μL) | 200 μL |
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HIRA Gene Summary
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
Gene Name: Histone Cell Cycle Regulator
Chromosome: CHR22: 19318223 -19419219
Locus: 22q11.21
NSMCE2 Gene Summary
This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]
Gene Name: NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase
Chromosome: CHR8: 126104082 -126379367
Locus: 8q24.13
Gene Diseases
The HIRA NSMCE2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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