HIRA-CABIN1 Fusion FISH Probe
The HIRA-CABIN1 Fusion FISH Probe is used to confirm a fusion of the HIRA and CABIN1 genes. The fusion of the HIRA and CABIN1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HIRA-CABIN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| HIRA-CABIN1-20-AQAQ | 20 (40 μL) | 200 μL |
|
HIRA Gene Summary
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
Gene Name: Histone Cell Cycle Regulator
Chromosome: CHR22: 19318223 -19419219
Locus: 22q11.21
CABIN1 Gene Summary
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
Gene Name: Calcineurin Binding Protein 1
Chromosome: CHR22: 24407764 -24574596
Locus: 22q11.23
Gene Diseases
The HIRA CABIN1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|