HIRA-ADAM2 Fusion FISH Probe
The HIRA-ADAM2 Fusion FISH Probe is used to confirm a fusion of the HIRA and ADAM2 genes. The fusion of the HIRA and ADAM2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HIRA-ADAM2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-RERE | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-REOR | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-REGO | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-REGR | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-REAQ | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-ORRE | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-OROR | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-ORGO | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-GORE | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-GOOR | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-GOGO | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-GOGR | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-GRRE | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-GROR | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-GRGO | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-GRGR | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-AQRE | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-AQOR | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-AQGO | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-AQGR | 20 (40 μL) | 200 μL |
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| HIRA-ADAM2-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAM2 Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Gene Name: ADAM Metallopeptidase Domain 2
Chromosome: CHR8: 39601254 -39695779
Locus: 8p11.22
HIRA Gene Summary
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
Gene Name: Histone Cell Cycle Regulator
Chromosome: CHR22: 19318223 -19419219
Locus: 22q11.21
Gene Diseases
The HIRA ADAM2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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