HIPK2-GRM8 Fusion FISH Probe
The HIPK2-GRM8 Fusion FISH Probe is used to confirm a fusion of the HIPK2 and GRM8 genes. The fusion of the HIPK2 and GRM8 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HIPK2-GRM8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-RERE | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-REOR | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-REGO | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-REGR | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-REAQ | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-ORRE | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-OROR | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-ORGO | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-ORAQ | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-GORE | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-GOOR | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-GOGO | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-GOGR | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-GOAQ | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-GRRE | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-GROR | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-GRGO | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-GRGR | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-GRAQ | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-AQRE | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-AQOR | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-AQGO | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-AQGR | 20 (40 μL) | 200 μL |
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| HIPK2-GRM8-20-AQAQ | 20 (40 μL) | 200 μL |
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GRM8 Gene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Glutamate Metabotropic Receptor 8
Chromosome: CHR7: 126078651 -126892428
Locus: 7q31.33
HIPK2 Gene Summary
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Homeodomain Interacting Protein Kinase 2
Chromosome: CHR7: 139246315 -139477693
Locus: 7q34
Gene Diseases
The HIPK2 GRM8 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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