HIPK2-ARPC1A Fusion FISH Probe
The HIPK2-ARPC1A Fusion FISH Probe is used to confirm a fusion of the HIPK2 and ARPC1A genes. The fusion of the HIPK2 and ARPC1A genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HIPK2-ARPC1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-RERE | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-REOR | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-REGO | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-REGR | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-REAQ | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-ORRE | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-OROR | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-ORGO | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-GORE | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-GOOR | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-GOGO | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-GOGR | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-GRRE | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-GROR | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-GRGO | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-GRGR | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-AQRE | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-AQOR | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-AQGO | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-AQGR | 20 (40 μL) | 200 μL |
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| HIPK2-ARPC1A-20-AQAQ | 20 (40 μL) | 200 μL |
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ARPC1A Gene Summary
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Name: Actin Related Protein 2/3 Complex Subunit 1A
Chromosome: CHR7: 98923495 -98963885
Locus: 7q22.1
HIPK2 Gene Summary
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Homeodomain Interacting Protein Kinase 2
Chromosome: CHR7: 139246315 -139477693
Locus: 7q34
Gene Diseases
The HIPK2 ARPC1A Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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