HINT2-NPR2 Fusion FISH Probe
The HINT2-NPR2 Fusion FISH Probe is used to confirm a fusion of the HINT2 and NPR2 genes. The fusion of the HINT2 and NPR2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HINT2-NPR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-RERE | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-REOR | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-REGO | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-REGR | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-REAQ | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-ORRE | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-OROR | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-ORGO | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-GORE | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-GOOR | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-GOGO | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-GOGR | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-GRRE | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-GROR | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-GRGO | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-GRGR | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-AQRE | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-AQOR | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-AQGO | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-AQGR | 20 (40 μL) | 200 μL |
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| HINT2-NPR2-20-AQAQ | 20 (40 μL) | 200 μL |
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NPR2 Gene Summary
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
Gene Name: Natriuretic Peptide Receptor 2
Chromosome: CHR9: 35792405 -35809728
Locus: 9p13.3
HINT2 Gene Summary
Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]
Gene Name: Histidine Triad Nucleotide Binding Protein 2
Chromosome: CHR9: 35812956 -35815042
Locus: 9p13.3
Gene Diseases
The HINT2 NPR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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