HIF1A-VRK1 Fusion FISH Probe
The HIF1A-VRK1 Fusion FISH Probe is used to confirm a fusion of the HIF1A and VRK1 genes. The fusion of the HIF1A and VRK1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HIF1A-VRK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-RERE | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-REOR | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-REGO | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-REGR | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-REAQ | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-ORRE | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-OROR | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-ORGO | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-GORE | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-GOOR | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-GOGO | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-GOGR | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-GRRE | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-GROR | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-GRGO | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-GRGR | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-AQRE | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-AQOR | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-AQGO | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-AQGR | 20 (40 μL) | 200 μL |
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| HIF1A-VRK1-20-AQAQ | 20 (40 μL) | 200 μL |
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HIF1A Gene Summary
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Gene Name: Hypoxia Inducible Factor 1 Alpha Subunit
Chromosome: CHR14: 62162118 -62214977
Locus: 14q23.2
VRK1 Gene Summary
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]
Gene Name: Vaccinia Related Kinase 1
Chromosome: CHR14: 97263683 -97347951
Locus: 14q32.2
Gene Diseases
The HIF1A VRK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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