HIF1A-PRKCH Fusion FISH Probe
The HIF1A-PRKCH Fusion FISH Probe is used to confirm a fusion of the HIF1A and PRKCH genes. The fusion of the HIF1A and PRKCH genes has been associated with Ovarian Serous Cystadenocarcinoma, Lung Adenocarcinoma, Uterine Corpus Endometrial Carcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HIF1A-PRKCH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-RERE | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-REOR | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-REGO | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-REGR | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-REAQ | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-ORRE | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-OROR | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-ORGO | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-ORAQ | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-GORE | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-GOOR | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-GOGO | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-GOGR | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-GOAQ | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-GRRE | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-GROR | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-GRGO | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-GRGR | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-GRAQ | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-AQRE | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-AQOR | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-AQGO | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-AQGR | 20 (40 μL) | 200 μL |
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| HIF1A-PRKCH-20-AQAQ | 20 (40 μL) | 200 μL |
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HIF1A Gene Summary
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Gene Name: Hypoxia Inducible Factor 1 Alpha Subunit
Chromosome: CHR14: 62162118 -62214977
Locus: 14q23.2
PRKCH Gene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]
Gene Name: Protein Kinase C Eta
Chromosome: CHR14: 61788514 -62017698
Locus: 14q23.1
Gene Diseases
The HIF1A PRKCH Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
| Lung Adenocarcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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