HERC6-CABP4 Fusion FISH Probe
The HERC6-CABP4 Fusion FISH Probe is used to confirm a fusion of the HERC6 and CABP4 genes. The fusion of the HERC6 and CABP4 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HERC6-CABP4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-RERE | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-REOR | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-REGO | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-REGR | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-REAQ | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-ORRE | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-OROR | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-ORGO | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-ORAQ | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-GORE | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-GOOR | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-GOGO | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-GOGR | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-GOAQ | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-GRRE | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-GROR | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-GRGO | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-GRGR | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-GRAQ | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-AQRE | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-AQOR | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-AQGO | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-AQGR | 20 (40 μL) | 200 μL |
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| HERC6-CABP4-20-AQAQ | 20 (40 μL) | 200 μL |
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HERC6 Gene Summary
HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Gene Name: HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase Family Member 6
Chromosome: CHR4: 89299890 -89364249
Locus: 4q22.1
CABP4 Gene Summary
This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: Calcium Binding Protein 4
Chromosome: CHR11: 67222817 -67229245
Locus: 11q13.2
Gene Diseases
The HERC6 CABP4 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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