HERC4-RUFY2 Fusion FISH Probe
The HERC4-RUFY2 Fusion FISH Probe is used to confirm a fusion of the HERC4 and RUFY2 genes. The fusion of the HERC4 and RUFY2 genes has been associated with Breast Invasive Carcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HERC4-RUFY2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-RERE | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-REOR | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-REGO | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-REGR | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-REAQ | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-ORRE | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-OROR | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-ORGO | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-GORE | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-GOOR | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-GOGO | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-GOGR | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-GRRE | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-GROR | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-GRGO | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-GRGR | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-AQRE | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-AQOR | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-AQGO | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-AQGR | 20 (40 μL) | 200 μL |
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| HERC4-RUFY2-20-AQAQ | 20 (40 μL) | 200 μL |
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HERC4 Gene Summary
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Gene Name: HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 4
Chromosome: CHR10: 69681655 -69835103
Locus: 10q21.3
RUFY2 Gene Summary
The RUN And FYVE Domain Containing 2 (RUFY2) gene is located on chr10 :70103274-70166946 at 10q21.3.
Gene Name: RUN And FYVE Domain Containing 2
Chromosome: CHR10: 70103274 -70166946
Locus: 10q21.3
Gene Diseases
The HERC4 RUFY2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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