HERC4-CTNNA3 Fusion FISH Probe
The HERC4-CTNNA3 Fusion FISH Probe is used to confirm a fusion of the HERC4 and CTNNA3 genes. The fusion of the HERC4 and CTNNA3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HERC4-CTNNA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-RERE | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-REOR | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-REGO | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-REGR | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-REAQ | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-ORRE | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-OROR | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-ORGO | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-GORE | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-GOOR | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-GOGO | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-GOGR | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-GRRE | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-GROR | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-GRGO | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-GRGR | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-AQRE | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-AQOR | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-AQGO | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-AQGR | 20 (40 μL) | 200 μL |
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| HERC4-CTNNA3-20-AQAQ | 20 (40 μL) | 200 μL |
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HERC4 Gene Summary
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Gene Name: HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 4
Chromosome: CHR10: 69681655 -69835103
Locus: 10q21.3
CTNNA3 Gene Summary
This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Name: Catenin Alpha 3
Chromosome: CHR10: 67679724 -69455949
Locus: 10q21.3
Gene Diseases
The HERC4 CTNNA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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