HERC4-CDKAL1 Fusion FISH Probe
The HERC4-CDKAL1 Fusion FISH Probe is used to confirm a fusion of the HERC4 and CDKAL1 genes. The fusion of the HERC4 and CDKAL1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HERC4-CDKAL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-RERE | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-REOR | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-REGO | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-REGR | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-REAQ | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-ORRE | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-OROR | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-ORGO | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-GORE | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-GOOR | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-GOGO | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-GOGR | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-GRRE | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-GROR | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-GRGO | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-GRGR | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-AQRE | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-AQOR | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-AQGO | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-AQGR | 20 (40 μL) | 200 μL |
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| HERC4-CDKAL1-20-AQAQ | 20 (40 μL) | 200 μL |
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HERC4 Gene Summary
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Gene Name: HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 4
Chromosome: CHR10: 69681655 -69835103
Locus: 10q21.3
CDKAL1 Gene Summary
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010]
Gene Name: CDK5 Regulatory Subunit Associated Protein 1 Like 1
Chromosome: CHR6: 20534687 -21232634
Locus: 6p22.3
Gene Diseases
The HERC4 CDKAL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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