HELZ-OAZ1 Fusion FISH Probe
The HELZ-OAZ1 Fusion FISH Probe is used to confirm a fusion of the HELZ and OAZ1 genes. The fusion of the HELZ and OAZ1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HELZ-OAZ1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-RERE | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-REOR | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-REGO | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-REGR | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-REAQ | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-ORRE | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-OROR | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-ORGO | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-GORE | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-GOOR | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-GOGO | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-GOGR | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-GRRE | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-GROR | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-GRGO | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-GRGR | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-AQRE | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-AQOR | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-AQGO | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-AQGR | 20 (40 μL) | 200 μL |
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| HELZ-OAZ1-20-AQAQ | 20 (40 μL) | 200 μL |
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OAZ1 Gene Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
Gene Name: Ornithine Decarboxylase Antizyme 1
Chromosome: CHR19: 2269519 -2273487
Locus: 19p13.3
HELZ Gene Summary
HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]
Gene Name: Helicase With Zinc Finger
Chromosome: CHR17: 65066553 -65241319
Locus: 17q24.2
Gene Diseases
The HELZ OAZ1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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