HEBP1-CREBL2 Fusion FISH Probe
The HEBP1-CREBL2 Fusion FISH Probe is used to confirm a fusion of the HEBP1 and CREBL2 genes. The fusion of the HEBP1 and CREBL2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HEBP1-CREBL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-RERE | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-REOR | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-REGO | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-REGR | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-REAQ | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-ORRE | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-OROR | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-ORGO | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-GORE | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-GOOR | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-GOGO | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-GOGR | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-GRRE | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-GROR | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-GRGO | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-GRGR | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-AQRE | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-AQOR | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-AQGO | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-AQGR | 20 (40 μL) | 200 μL |
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| HEBP1-CREBL2-20-AQAQ | 20 (40 μL) | 200 μL |
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CREBL2 Gene Summary
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Name: CAMP Responsive Element Binding Protein Like 2
Chromosome: CHR12: 12764830 -12798041
Locus: 12p13.1
HEBP1 Gene Summary
The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]
Gene Name: Heme Binding Protein 1
Chromosome: CHR12: 13127798 -13153243
Locus: 12p13.1
Gene Diseases
The HEBP1 CREBL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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