HEATR3-CHRNB3 Fusion FISH Probe
The HEATR3-CHRNB3 Fusion FISH Probe is used to confirm a fusion of the HEATR3 and CHRNB3 genes. The fusion of the HEATR3 and CHRNB3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HEATR3-CHRNB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-RERE | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-REOR | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-REGO | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-REGR | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-REAQ | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-ORRE | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-OROR | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-ORGO | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-GORE | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-GOOR | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-GOGO | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-GOGR | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-GRRE | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-GROR | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-GRGO | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-GRGR | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-AQRE | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-AQOR | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-AQGO | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-AQGR | 20 (40 μL) | 200 μL |
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| HEATR3-CHRNB3-20-AQAQ | 20 (40 μL) | 200 μL |
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CHRNB3 Gene Summary
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]
Gene Name: Cholinergic Receptor Nicotinic Beta 3 Subunit
Chromosome: CHR8: 42552561 -42592209
Locus: 8p11.21
HEATR3 Gene Summary
The protein encoded by this gene plays a role in ribosomal protein transport and in the assembly of the 5S ribonucleoprotein particle (5S RNP). The encoded protein also may be involved in NOD2-mediated NF-kappaB signaling. [provided by RefSeq, Jul 2016]
Gene Name: HEAT Repeat Containing 3
Chromosome: CHR16: 50099880 -50139375
Locus: 16q12.1
Gene Diseases
The HEATR3 CHRNB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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